About
Cohort overview
Differential Expression Analysis
Summary table
Model results
Correlations
Single gene
Single measure
Multiple measures
Modules heatmap
Compare trajectories
Clinical trajectory of patients
Profile settings
Select measures variable for trajectory:
PASI
BSA
Select variable for trajectory color:
TransformedDeltaPASI
PASI_wk00
PASI_wk01
PASI_wk04
PASI_wk12
Drug
order by color variable?
Summary of differential expression models hits
Individual model results
Select category:
Disease Activity
Select model:
1
Plot options
FC threshold:
Significance threshold:
Use adjusted p-value?
Gene labels:
Significant only
From list
Comma-separated list of gene symbols to highlight:
Download table
Correlation between a selected gene and measures
Select a gene:
*
Sample selection
Time points subset
Baseline
Week 1
Week 4
Week 12
Tissues subset
Lesional
Nonlesional
Blood
Drug subset
Adalimumab
Ustekinumab
All
Cohort subset
Discovery
Replication
Plot options
Select color:
None
Sex
PASI75
PsoriaticArthritis
BiologicNaive
Drug
Other options
Remove measures outliers?
5/95 percentiles
IQR
No
Correlation method:
Pearson
Spearman
Kendall
Fitting method:
Linear
Quadratic
Cubic
Transcript not found in subset or subset combination does not exist.
No gene selected
Disease Activity
Lab Tests Baseline
Lab Tests Week 4
Lab Tests Week 12
Correlation between all genes and a selected measure
Select a measure:
*
TransformedDeltaPASI
PASI_wk00
PASI_wk01
PASI_wk04
PASI_wk12
BSA_wk00
BSA_wk01
BSA_wk04
BSA_wk12
DLQI_wk00
DLQI_wk01
DLQI_wk04
DLQI_wk12
Sample selection
Time points subset
Baseline
Week 1
Week 4
Week 12
Tissues subset
Lesional
Nonlesional
Blood
Drug subset
Adalimumab
Ustekinumab
All
Cohort subset
Discovery
Replication
Other options
Remove measures outliers?
5/95 percentiles
IQR
No
Correlation method:
Pearson
Spearman
Kendall
No measure selected
Download Table CSV
Correlation between all genes and measures
Select set of measures:
*
PASI
BSA
DLQI
Lab tests
Sample selection
Time points subset
Baseline
Week 1
Week 4
Week 12
Tissues subset
Lesional
Nonlesional
Blood
Drug subset
Adalimumab
Ustekinumab
All
Cohort subset
Discovery
Replication
Plot options
Maximum p-value for label:
Use adjusted p-value?
Minimum correlation for label:
Other options
Remove measures outliers?
5/95 percentiles
IQR
No
Correlation method:
Pearson
Spearman
Kendall
Select a set of measures to view heatmap and table
Download as CSV with p-values
Select subsets and a module to view heatmap of genes
Select category:
WGCNA Blood
WGCNA Skin
Blood factors
Skin factors
Sample selection
Time points subset
Baseline
Week 1
Week 4
Week 12
Tissues subset
Lesional
Nonlesional
Blood
Drug subset
Adalimumab
Ustekinumab
All
Cohort subset
Discovery
Replication
Select heatmap annotations:
Sex
Drug
DeltaPASI
TransformedDeltaPASI
PASI75
PASI_wk00
PASI_wk01
PASI_wk04
PASI_wk12
BloodDiseaseEndotype
BloodResponseEndotype
LesionalDiseaseEndotype
LesionalResponseEndotype
NonlesionalDiseaseEndotype
NonlesionalResponseEndotype
Cw6_status
Cw6_Dosage
BiologicNaive
PsoriaticArthritis
Flexural
Soles
Palms
Nails
Scalp
FitzpatrickScore
Age
AgeAtOnset
BMI_wk00
BMI_wk01
BMI_wk04
BMI_wk12
Diastolic_wk00
Diastolic_wk01
Diastolic_wk04
Diastolic_wk12
Systolic_wk00
Systolic_wk01
Systolic_wk04
Systolic_wk12
SmokingStatus
View genes
Association of measures with module eigengene
Comparison of expression between drug subgroups across time
Select a gene:
*
Select a measure:
*
PASI
BSA
DLQI
Sample selection
Tissues subset
Lesional
Nonlesional
Blood
Cohort subset
Discovery
Replication
Other options
Fitting method:
Linear
Quadratic
Cubic
None